Transitory loss of glia and the subsequent modulation in inflammatory cytokines/chemokines regulate paracellular claudin-5 expression in endothelial cells
作者： Ryan B. Camire , Holly J. Beaulac , Colin L. Willis
DOI: 10.1016/J.JNEUROIM.2015.05.008
关键词:
摘要: Abstract Signaling mechanisms involved in regulating blood–brain barrier (BBB) integrity during central nervous system (CNS) inflammation remain unclear. We show that an imbalance between pro-/anti-inflammatory cytokines/chemokines alters claudin-5 expression. In vivo , gliotoxin-induced changes glial populations and cytokine/chemokine expression occurred as BBB was compromised. The balance restored re-established. vitro TNF-α, IL-6, MCP-1 induced paracellular loss. TNF-α- IL-6- effects were mediated through the PI3K pathway IL-10 attenuated TNF-α's effect. This study shows modulators play a critical role CNS inflammation.
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