A Genome Wide Association Study of Hepatitis B Vaccine Response in an Indonesian Population Reveals Multiple Independent Risk Variants in the HLA Region
作者： E. Png , A. Thalamuthu , R. T. H. Ong , H. Snippe , G. J. Boland
DOI: 10.1093/HMG/DDR302
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摘要: We performed a two-stage genome-wide association study (GWAS) of antibody titer in 3614 hepatitis B vaccine recipients from Indonesia’s Riau Archipelago, leading to the identification at least three independent signals within human leukocyte antigen (HLA) complex. These appear implicate HLA-DR [rs3135363; P 5 6.53 3 10 222 ; odds ratio (OR) 1.53, 95% confidence interval (CI) 1.35 –1 .74]; HLA-DP, previously associated with risk chronic infection (rs9277535; 2.91 212 ;O R5 0.72, CI 0.63–0.81); and gene rich HLA Class III (rs9267665; 1.24 217 2.05, 1.64–2.57). The substantial overlap these variants those identified by GWAS confirms response as model for infection, while suggesting that is effective most lifelong following exposure virus.
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