Pharmakokinetische Besonderheiten des Tetanustoxins und ihre Beziehungen zur Pathogenese des lokalen bzw. generalisierten Tetanus

摘要: 1. The preparation and properties of125I-labelled tetanus toxin are described. 2. After intravenous injection there is a short phase when the labelled rapidly removed from blood plasma. This initial period followed by slow second of decay which has longer duration. The first in very pronounced rabbits, but not rats. Unlabelled equally fast rabbit plasma, as been revealed measuring immunological reactivity (so-called “junction test”) toxicity. 3. Thirty minutes after i.v. administration torabbits about 2/3 radioactive label found liver. highest concentration attained spleen. 24 hours later, bulk excreted urine faeces, indicates catabolism toxin. In therat, liver much less prominent, excretion slower. both species, central nervous system does accumulate more than just measurable quantities label, even if animals given large toxic doses. 4. After into left gastrocnemius muscle rat, absorbed slowly site administration. It taken up corresponding N. ischiadicus lumbar region spinal cord. anterior leg leads to radioactivity cervical area medulla. arrival cord coincides approximately with appearance local tetanus. Sectioning prevents lower extremity. enrichment prevented operated, sham-operated rats. 5. When was subdivided four sectors, be greatly concentrated ipsilateral ventral sector segment injected transport roots. 6. 131I-labelled antitoxin also disappears rat gastrocnemius. contrast toxin, however, it