Activity of intravenous menogaril in patients with previously untreated metastatic breast cancer. A National Cancer Institute of Canada Clinical Trials Group study.
作者： ElizabethA. Eisenhauer , KathleenI. Pritchard , DanieleJ. Perrault , Shailendra Verma , JosephL. Pater
DOI: 10.1007/BF00171838
关键词:
摘要: We have carried out a phase II study of intravenous menogaril given every four weeks in group patients with breast cancer who had received no prior chemotherapy for metastatic disease. Myelosuppression, nausea and vomiting local reactions were seen frequently. Six partial responses (median duration 154 days) 24 eligible patients. conclude is active recommend that because it can be delivered high doses orally, future trials this disease should focus on intense oral schedule.
springer.com
sci-hub.se 参考文章(8)
P Dodion, C Sessa, R Joss, N Crespeigne, Y Willems, M Kitt, J Abrams, C Finet, J E Brewer, W J Adams, Phase I study of intravenous menogaril administered intermittently. Journal of Clinical Oncology. ,vol. 4, pp. 767- 774 ,(1986) , 10.1200/JCO.1986.4.5.767
B. Hoogstraten, S. L. George, B. Samal, S. E. Rivkin, J. J. Costanzi, J. D. Bonnet, T. Thigpen, H. Braine, Combination chemotherapy and adriamycin in patients with advanced breast cancer. A Southwest Oncology Group study Cancer. ,vol. 38, pp. 13- 20 ,(1976) , 10.1002/1097-0142(197607)38:1<13::AID-CNCR2820380104>3.0.CO;2-5
C. Sessa, S. Gundersen, W. ten Bokkel Huinink, J. Renard, F. Cavalli, Phase II Study of Intravenous Menogaril in Patients With Advanced Breast Cancer Journal of the National Cancer Institute. ,vol. 80, pp. 1066- 1069 ,(1988) , 10.1093/JNCI/80.13.1066
Jeffrey A. Gottlieb, Saul E. Rivkin, Stuart C. Spigel, Barth Hoogstraten, Robert M. O'Bryan, Fred C. Delaney, Amnuay Singhakowinta, Superiority of adriamycin over oral nitrosoureas in patients with advanced breast carcinoma.A southwest cancer chemotherapy study group study Cancer. ,vol. 33, pp. 519- 526 ,(1974) , 10.1002/1097-0142(197402)33:2<519::AID-CNCR2820330229>3.0.CO;2-X
A. J. Schutt, C. G. Moertel, H. J. Long, Garth Powis, Phase I and pharmacokinetic study of menogaril administered as a 72-hour continuous iv infusion Cancer treatment reports. ,vol. 71, pp. 593- 598 ,(1987)
McGovren Jp, Activity of the anthracycline agent, 7-con-O-methylnogarol (7-OMEN), administered orally to mice bearing P388 or L1210 leukemia. Cancer treatment reports. ,vol. 64, pp. 727- ,(1980)
Hahn Rg, Eagan Rt, Ahmann Dl, Edmonson Jh, Bisel Hf, Controlled evaluation of adriamycin (NSC-123127) in patients with disseminated breast cancer. Cancer chemotherapy reports. ,vol. 58, pp. 877- ,(1974)
McGovren Jp, Kuentzel Sl, Neil Gl, Treatment of mouse tumors with 7-con-O-methylnogarol and other analogs of the anthracycline antibiotic, nogalamycin. Cancer treatment reports. ,vol. 63, pp. 1971- ,(1979)