Control of Actin Dynamics by Allosteric Regulation of Actin Binding Proteins

摘要: Abstract The regulated assembly and organization of actin filaments allows the cell to construct a large diversity actin-based structures specifically suited range cellular processes. A vast array regulatory proteins must work in concert form specific networks within cells, spatial temporal requirements for necessitate rapid regulation protein activity. This chapter explores common mechanism controlling activity binding proteins: allosteric autoinhibition by interdomain head–tail interactions. Intramolecular interactions maintain these closed conformation that masks domains needed regulate dynamics. Autoinhibition is typically relieved two or more ligand and/or posttranslational modification events expose key domains. Regulation through multiple inputs permits precise control guide network formation.