Impact of paravalvular aortic regurgitation after transcatheter aortic valve implantation on survival.

摘要: Abstract Objectives To determine whether ≥moderate paravalvular aortic regurgitation (PAR) after transcatheter valve implantation (TAVI) independently impairs overall survival and how much the impact on is, we performed an updated meta-analysis pooling not unadjusted but adjusted hazard ratios (HRs). Methods Databases including MEDLINE EMBASE were searched through January 2016 using PubMed OVID. Search terms included or perivalvular ; , leak leakage percutaneous transluminal transarterial transapical transaortic transcarotid transaxillary transsubclavian transiliac transfemoral transiliofemoral . Studies considered for inclusion met following criteria: design was observational comparative study; study population patients undergoing TAVI; divided into ≤mild post-TAVI PAR; outcomes ≥1-year all-cause mortality; adjustment method a multivariate Cox proportional hazards analysis. An HR with its 95% confidence interval (CI) PAR abstracted from each individual study. Results Our search identified 17 eligible studies total of 15,131 patients. A pooled analysis all demonstrated statistically significant 2.12-fold increase in mortality (HR, 2.12; CI, 1.79 to 2.51; p Conclusions ≥Moderate is associated (≥1-year) mortality.