Clinical and genetic correlates of soluble P-selectin in the community.

摘要: Summary.  Background:  P-selectin is a cell adhesion molecule that involved in atherogenesis, and soluble concentrations of this biomarker reflect cardiovascular risk. However, the clinical correlates genetic characterization have not been clearly elucidated. Objective:  To describe circulating community. Methods:  In Framingham Heart Study Offspring (European descent) Omni (ethnic/racial minority) participants, we examined association risk factors with concentrations. evaluated heritability, linkage 29 SELP single-nucleotide polymorphisms (SNPs) adjusted concentrations. Results:  multivariable analysis 3690 participants (54% women, mean age 60 ± 10 years), higher log-transformed were inversely associated female sex hormone replacement therapy, positively age, ethnic/racial minority status, cigarette smoking, waist circumference, systolic blood pressure, fasting glucose, total/high-density lipoprotein cholesterol triglyceride Clinical explained 10.4% interindividual variability 571 extended pedigrees (n = 1841) ≥ 2 phenotyped members per family, multivariable-adjusted heritability was 45.4 ± 5.8%. Among SNPs examined, non-synonymous SNP (rs6136) encoding threonine-to-proline substitution at position 715 highly significantly decreased (P = 5.2 × 10−39), explaining 9.7% variation after adjustment for factors. Conclusions:  Multiple an gene One significant concentrations, even accounting known correlates.