Ribozyme-mediated repair of defective mRNA by targeted trans -splicing
作者： Bruce A. Sullenger , Thomas R. Cech
DOI: 10.1038/371619A0
关键词:
摘要: … ' 9 ' 10 • Such trans-cleaving ribozymes join a growing list of agents that stop the flow of … of ribozymes for which they may be uniquely suited. By targeted trans-splicing, a ribozyme can …
nature.com
harvard.edu
springer.com
sci-hub.se 参考文章(28)
T.R. Cech, D Herschlag, J.A. Piccirilli, A.M. Pyle, RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization. Journal of Biological Chemistry. ,vol. 267, pp. 17479- 17482 ,(1992) , 10.1016/S0021-9258(19)37064-4
Flossie Wong-Staal, Mang Yu, Eric Poeschla, Progress towards gene therapy for HIV infection. Gene Therapy. ,vol. 1, pp. 13- 26 ,(1994)
Jeffrey H Miller, Experiments in molecular genetics ,(1972)
Didier Trono, Mark B. Feinberg, David Baltimore, HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus Cell. ,vol. 59, pp. 113- 120 ,(1989) , 10.1016/0092-8674(89)90874-X
Richard B. Waring, Paul Towner, Stephen J. Minter, R. Wayne Davies, Splice-site selection by a self-splicing RNA of tetrahymena Nature. ,vol. 321, pp. 133- 139 ,(1986) , 10.1038/321133A0
Jim Haseloff, Wayne L. Gerlach, Simple RNA enzymes with new and highly specific endoribonuclease activities Nature. ,vol. 334, pp. 585- 591 ,(1988) , 10.1038/334585A0
D. Herschlag, Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 6921- 6925 ,(1991) , 10.1073/PNAS.88.16.6921
Michael H. Malim, Sabine Böhnlein, Joachim Hauber, Bryan R. Cullen, Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function Cell. ,vol. 58, pp. 205- 214 ,(1989) , 10.1016/0092-8674(89)90416-9
Eli Gilboa, Clay Smith, Gene therapy for infectious diseases: the AIDS model Trends in Genetics. ,vol. 10, pp. 139- 144 ,(1994) , 10.1016/0168-9525(94)90216-X
Thomas R. Cech, Ribozymes and Their Medical Implications JAMA: The Journal of the American Medical Association. ,vol. 260, pp. 3030- 3034 ,(1988) , 10.1001/JAMA.1988.03410200086031