The gene for the RNA component of the mitochondrial RNA-processing endoribonuclease is located on human chromosome 9p and on mouse chromosome 4.

摘要: Abstract Mitochondrial RNA-processing endoribonuclease (RNAase MRP) has the capacity to cleave mitochondrial RNA complementary light strand of displacement loop at a unique site. The enzyme is ribonucleoprotein whose component nuclear gene product. 5′ flanking region primary transcript control elements characteristic polymerase II transcription, and coding features III transcription signals. associated with RNAase MRP first known encoded by single-copy in nucleus believed be imported into mitochondria. (RMRP) for this was assigned human chromosome 9 mouse 4 Southern blot analyses 11 × rodent hybrids probe pHM1.0 pSP270, respectively. In situ hybridization pHSTU300 normal chromosomes revealed 29 100 cells label on 9p 9.6% 302 silver grains located 9p21-p12.