hnRNP G: sequence and characterization of a glycosylated RNA-binding protein

摘要: The autoantigen p43 is a nuclear protein initially identified with autoantibodies from dogs lupus-like syndrome. Here we show that an RNA-binding protein, and identify it as hnRNP G, previously described component of heterogeneous ribonucleoprotein complexes. We demonstrate p43/hnRNP G glycosylated, the modification O-linked N-acetylglucosamine. A full-length cDNA clone for has been isolated sequenced, predicted amino acid sequence shows contains one RNP-consensus RNA binding domain (RBD) at terminus carboxyl rich in serines, arginines glycines. RBD human striking similarities RBDs several plant proteins.