Opportunistic Screening for Osteoporosis Using Body CT Scans Obtained for Other Indications: the UW Experience

作者: Scott J. Lee , Perry J. Pickhardt

DOI: 10.1007/S12018-017-9235-7

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摘要: Low bone mineral density (osteoporosis and osteopenia) leading to fragility fractures is associated with significant morbidity mortality in our aging population. This condition grossly underdiagnosed due both insufficient screening its silent nature prior complicating fractures. Body CT scans are commonly obtained among older adults for a wide variety of indications contain rich data regarding health that often ignored. At the University Wisconsin, we have sought harness this information “opportunistic” osteoporosis screening. In article, review various CT-based approaches taken date, including routine assessment spine vertebral trabecular density, as well hip, deriving femoral neck T-scores essentially equivalent dual-energy x-ray absorptiometry (DXA). Future directions research clinical implementation also discussed.

参考文章(43)
P. J. Pickhardt, T. Lauder, B. D. Pooler, A. Muñoz del Rio, H. Rosas, R. J. Bruce, N. Binkley, Effect of IV contrast on lumbar trabecular attenuation at routine abdominal CT: correlation with DXA and implications for opportunistic osteoporosis screening. Osteoporosis International. ,vol. 27, pp. 147- 152 ,(2016) , 10.1007/S00198-015-3224-9
S. J. Lee, N. Binkley, M. G. Lubner, R. J. Bruce, T. J. Ziemlewicz, P. J. Pickhardt, Opportunistic screening for osteoporosis using the sagittal reconstruction from routine abdominal CT for combined assessment of vertebral fractures and density. Osteoporosis International. ,vol. 27, pp. 1131- 1136 ,(2016) , 10.1007/S00198-015-3318-4
Jeff L. Fidler, Naveen S. Murthy, Sundeep Khosla, Bart L. Clarke, David H. Bruining, David L. Kopperdahl, David C. Lee, Tony M. Keaveny, Comprehensive Assessment of Osteoporosis and Bone Fragility with CT Colonography Radiology. ,vol. 278, pp. 172- 180 ,(2016) , 10.1148/RADIOL.2015141984
Timothy J. Ziemlewicz, Neil Binkley, Perry J. Pickhardt, Opportunistic Osteoporosis Screening: Addition of Quantitative CT Bone Mineral Density Evaluation to CT Colonography Journal of The American College of Radiology. ,vol. 12, pp. 1036- 1041 ,(2015) , 10.1016/J.JACR.2015.04.018
Tony M. Keaveny, Biomechanical computed tomography-noninvasive bone strength analysis using clinical computed tomography scans Annals of the New York Academy of Sciences. ,vol. 1192, pp. 57- 65 ,(2010) , 10.1111/J.1749-6632.2009.05348.X
J. A. Cauley, D. E. Thompson, K. C. Ensrud, J. C. Scott, D. Black, RISK OF MORTALITY FOLLOWING CLINICAL FRACTURES Osteoporosis International. ,vol. 11, pp. 556- 561 ,(2000) , 10.1007/S001980070075
Z. Wang, M. M. Ward, L. Chan, T. Bhattacharyya, Adherence to oral bisphosphonates and the risk of subtrochanteric and femoral shaft fractures among female medicare beneficiaries Osteoporosis International. ,vol. 25, pp. 2109- 2116 ,(2014) , 10.1007/S00198-014-2738-X
Ramit Lamba, John P. McGahan, Michael T. Corwin, Chin-Shang Li, Tien Tran, J. Anthony Seibert, John M. Boone, CT Hounsfield numbers of soft tissues on unenhanced abdominal CT scans: variability between two different manufacturers' MDCT scanners American Journal of Roentgenology. ,vol. 203, pp. 1013- 1020 ,(2014) , 10.2214/AJR.12.10037
Caroline S. Fox, Joseph M. Massaro, Udo Hoffmann, Karla M. Pou, Pal Maurovich-Horvat, Chun-Yu Liu, Ramachandran S. Vasan, Joanne M. Murabito, James B. Meigs, L. Adrienne Cupples, Ralph B. D’Agostino, Christopher J. O’Donnell, Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. ,vol. 116, pp. 39- 48 ,(2007) , 10.1161/CIRCULATIONAHA.106.675355