Efficacy of Acute Intermittent Hypoxia on Physical Function and Health Status in Humans with Spinal Cord Injury: A Brief Review

摘要: Spinal cord injury (SCI) results in a loss of motor and sensory function is consequent with reductions locomotion, leading to relatively sedentary lifestyle which predisposes individuals premature morbidity mortality. Many exercise modalities have been employed improve physical health status SCI, yet they are typically expensive, require many trained clinicians implement, thus relegated specialized rehabilitation centers. These characteristics traditional exercise-based SCI make their application impractical considering the time-intensive nature these regimens patients' poor access exercise. A promising approach persons exposure acute intermittent hypoxia (IH) form small amount sessions brief, repeated exposures low oxygen gas mixtures interspersed normoxic breathing. This review summarizes clinical IH humans describes recommended dosing potential side effects IH, reviews existing data concerning efficacy brief modify function. Potential mechanisms explaining also discussed. Collectively, appears be safe, time-efficient, robust enhance chronic, incomplete SCI.