Mitochondrial dysfunction in neurological disorders with epileptic phenotypes
作者： Gábor Zsurka , Wolfram S. Kunz
DOI: 10.1007/S10863-010-9314-7
关键词:
摘要: A broad variety of mutations the mitochondrial DNA or nuclear genes that lead to impairment respiratory chain ATP synthesis have been associated with epileptic phenotypes. Additionally, evidence for an impaired function in seizure focus patients temporal lobe epilepsy and Ammon’s horn sclerosis, as well as, animal models has accumulated. This implies a direct pathogenic role dysfunction process epileptogenesis generation certain forms epilepsy.
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