Influence of body composition and muscle strength on outcomes after multimodal oesophageal cancer treatment

摘要: Background: Influence of sarcopenia in combination with other body composition parameters and muscle strength on outcomes after oesophageal surgery for cancer remains unclear. The objectives were (i) to describe the incidence relation adipose tissue quantity distribution strength; (ii) evaluate if neoadjuvant chemoradiation (nCRTx) influences (iii) influence post-operative morbidity long-term survival. Methods: This retrospective study included patients who received nCRTx followed by between January 2011 2016. Skeletal muscle, visceral, subcutaneous cross-sectional areas calculated based computed tomography scans, was measured using hand grip tests, 30 seconds chair stand maximal inspiratory expiratory pressure tests prior nCRTx. Results: A total 322 this study. Sarcopenia present 55.6% 58.2% (P = 0.082). Patients had a significantly lower higher fat percentage. increased while mean mass index percentage decreased during above 25 kg/m2 associated anastomotic leakage (P = 0.032). Other not morbidity. handgrip pulmonary cardiac complications (P = 0.023 P = 0.009, respectively). In multivariable analysis, number stands test (hazard ratio 0.93, 95% confidence interval 0.87–0.99, P = 0.017) visceral >128 cm2 1.81, 1.30–2.53, P = 0.001) worse overall Conclusions: occurs frequently is less Body changes did Impaired high amount are Therefore, poor fitness might benefit from preoperative nutritional strengthening guidance, aiming increase decrease tissue. However, should be confirmed large prospective