摘要: Opioids are compounds that work at specific receptors in the brain to provide analgesia. Originally extracted from sap of poppy plant, opioids may be naturally occurring, semisynthetic, or synthetic, and their clinical activity is a function affinity for opioid brain. useful wide variety painful conditions, including acute pain, cancer chronic as well cough suppression air hunger. However, use associated with significant risk addiction potential, which limits contributes current “opioid phobia.” In this chapter, we will discuss history, pharmacology, uses, future directions.