Methods of identifying somatic mutational signatures for early cancer detection

摘要: Aspects of the invention include methods and systems for identifying somatic mutational signatures detecting, diagnosing, monitoring and/or classifying cancer in a patient known to have, or suspected having cancer. In various embodiments, use non-negative matrix factorization (NMF) approach construct signature that can be used identify latent sample detection classification some may principal components analysis (PCA) vector quantization (VQ) approaches matrix.