Studies on the anti-diarrheal properties of seed extract of Monodora tenuifolia

摘要: Summary: The anti-diarrheal effect of methanol extract (ME) seeds Monodora tenuifolia Benth (Annonaceae), a wildly growing orchid flowering tree whose seed is traditionally used as antidiarrhea remedy, was studied using rodent models diarrhea, enteropooling and gastrointestinal motility induced by castor oil. Acute toxicity lethality (LD 50 ) phytochemical constituents ME were also evaluated. results showed that significantly ( P <0.05) reduced the watery texture number fecal droppings over 4 h. It volume weight intestinal content in non-dose-related manner. On gastro-intestinal motility, small transit charcoal meal mice oil Phytochemical analysis tested positive to carbohydrates, saponins, proteins, resins, flavonoids, alkaloids, terpenoids, steroids, fats studies on revealed an oral LD greater than 5000 mg/kg mice. These M. possess properties mediated through inhibition hyper-secretion which substantiate use treatment diarrhea traditional medicine. Industrial relevance: industrial relevance findings from this study derives possibility formulating powdered plant or its alcohol extract, into herbal anti-diarrhea remedy. From age long condiment, may not preclude medicament.