Compositions for the Treatment or Prophylaxis of Viral Infections

作者: Jan Balzarini , Sonsoles Velazquez , Maria Jose Camarasa

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摘要: A compound of the general formula (III): wherein X is O, S, NH or CH 2 ; Y S NH; Z R 1 C 1-8 alkyl, especially 1-6 preferably n-alkyl, e.g., n-pentyl n-hexyl; at least one and 3 H—[R 4 -R 5 ] n —R 6 —, in which: — comprises an oligopeptide, being amino acid selected from proline, alanine, hydroxyproline, dihydroxyproline, thiazolidinecarboxylic (thioproline), dehydroproline, pipecolic (L-homoproline), azetidinecarboxylic acid, aziridinecarboxylic glycine, serine, valine, leucine, isoleucine threonine, a neutral, non-polar moiety that bonded to by peptide bond, 1, 2, 3, 5; other ]n-R H; pharmaceutically acceptable salt thereof.

参考文章(4)
Christopher McGuigan, Jan Balzarini, Anti-viral pyrimidine nucleoside analogues ,(2001)
Jean-Louis Imbach, Martin L. Bryant, Gilles Gosselin, 3'-prodrugs of 2'-deoxy-.beta.-l-nucleosides ,(2001)
Marco Migliore, Christopher McGuigan, Jan Balzarini, Anti-viral pyrimidine nucleoside derivatives ,(2007)
C. McGuigan, R. N. Pathirana, M. Migliore, R. Adak, G. Luoni, A. T. Jones, A. Diez-Torrubia, M.-J. Camarasa, S. Velazquez, G. Henson, E. Verbeken, R. Sienaert, L. Naesens, R. Snoeck, G. Andrei, J. Balzarini, Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus Journal of Antimicrobial Chemotherapy. ,vol. 60, pp. 1316- 1330 ,(2007) , 10.1093/JAC/DKM376