Tumor radiosensitivity and proliferation as parameters for optimizing radiotherapy

摘要: Radiotherapy is a widely used method to treat malignant tumors. However, the sensitivity treatment varies between tumors, and local tumor control not always achieved. The balance success side effects of affords important information for developing schedules at patient population level. Conversely there are no methods tailor in an individual clinical practice. purpose such would be better with individual, hopefully avoiding unnecessary treatments. As some tumors resistant radiotherapy doses that may delivered without severe effects, finding sensitize cells major importance. In Paper I we evaluated radiobiology model predicting surviving fraction (SF) five lung cancer cell lines. was see whether it include proliferation during fractionated formula based on radiosensitivity, number cells. When clonogenic assay establish SF, including seems predict SF after radiation than using inherent radiosensitivity alone. II same material head neck carcinomas. 18 patients compared patient-specific radiobiological parameters averages. Sensitivity recurrence predictive values were both accuracy calculated probability patientspecific-parameter reached borderline statistical significance (p = 0.07). III investigated entire carcinoma patients, those receiving brachytherapy (TCP) biologically effective dose (BED). Again averages calculate TCPs. Evaluating ROC curve demonstrated statistically significant difference discriminating or when specific parameters. This seen IV, role phosphine gold(I) compound altering radioresistance radioresistant human line U1810 investigated. effect achieved by shifting intracellular redox inhibiting TrxR. After single clinically relevant doses, clear radio-sensitizing repopulation demonstrated. Gene expression analysis genetic changes related cellular pathways connected DNA repair, response stress, cycle. ISBN 978-91-7457-800-3