Assessing human exposure to inorganic arsenic in high-arsenic areas of Latium: a biomonitoring study integrated with indicators of dietary intake.

摘要: Background: In Latium (central Italy), arsenic concentrations exceeding the regulatory limit of 10 μg/L for drinking water are present in groundwater from a large area volcanic origin. At least part area, high have been detected also soil and phytoavailable geogenic enters food chain. As result, local population may be exposed to inorganic via through consumption with higher than background concentrations. Methods: A cross sectional study was conducted assess exposure metabolism 269 residents 27 municipalities provinces Viterbo, Rome Latina. Total toenails sum methylated metabolites urine, latter determined by HPLC-ICPMS, were used as biomarkers exposure. All subjects involved provided samples water(s) cooking well detailed information on use. To get an insight into dietary intake locally-processed food, bread collected affected three compared levels reference areas. Results: 30% sample bottled or resorted treatment order lower content <10 (Group 1), 51% drank tap only 2), 19% both 3). Nail Group 2 3 1, whereas all groups had nail group. The related urine other two groups, 1. White showed significantly Conclusions: Use toenail biomarker long-term allowed retrospectively reconstruct irrespective recent modifications due changes 3, urinary concentration exceeded upper range Italian population. Inter-individual variability efficiency substantial indicating that subgroup is more susceptible toxic effects owing methylation capability.