Immunotherapy of b cell involvement in progression of solid, nonlymphoid tumors

作者: Emilio Barbera-Guillem

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摘要: A method for treating a pro-tumor immune response in an individual having, or suspected of response, by administering therapeutically effective amount immunotherapeutic composition which binds to determinant on B cells, resulting cell depletion including cells that may be involved promotion tumor progression. Also provided are compositions can used response.

参考文章(17)
V. Diehl, A. Lister, J.A. Radford, D. Ma, P. Johnson, A. Engert, F. Reyes, C. Haioun, H. Tilly, R. Capdeville, B. Coiffier, N. Ketterer, M. Feuring Buske, Rituximab (Anti-CD20 Monoclonal Antibody) for the Treatment of Patients With Relapsing or Refractory Aggressive Lymphoma: A Multicenter Phase II Study Blood. ,vol. 92, pp. 1927- 1932 ,(1998) , 10.1182/BLOOD.V92.6.1927
David G. Maloney, Antonio J. Grillo-López, Christine A. White, David Bodkin, Russell J. Schilder, James A. Neidhart, Nalini Janakiraman, Kenneth A. Foon, Tina-Marie Liles, Brian K. Dallaire, Ken Wey, Ivor Royston, Thomas Davis, Ronald Levy, IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma Blood. ,vol. 90, pp. 2188- 2195 ,(1997) , 10.1182/BLOOD.V90.6.2188
Nelson N. H. Teng, Marcia M. Bieber, Neelima M. Bhat, Method of killing B cells using antibodies which bind CDIM ,(1995)
Emilio Barbera-Guillem, Site-directed chemotherapy of metastases ,(1998)
Lionel A. Manson, Anti-tumor Immune Responses of the Tumor-Bearing Host: The Case for Antibody-Mediated Immunologic Enhancement Clinical Immunology and Immunopathology. ,vol. 72, pp. 1- 8 ,(1994) , 10.1006/CLIN.1994.1099
Zhihai Qin, Günther Richter, Thomas Schüler, Sabrina Ibe, Xuetao Cao, Thomas Blankenstein, B cells inhibit induction of T cell-dependent tumor immunity. Nature Medicine. ,vol. 4, pp. 627- 630 ,(1998) , 10.1038/NM0598-627
Emilio Barbera-Guillem, M. Bud Nelson, Barbara Barr, Julie K. Nyhus, Kenneth F. May Jr., Lan Feng, James W. Sampsel, B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion. Cancer Immunology, Immunotherapy. ,vol. 48, pp. 541- 549 ,(2000) , 10.1007/PL00006672