Behavioural and biochemical effects of 2‐(2,6‐dichlorophenylamino)‐2‐imidazoline hydrochloride (St 155) on the central nervous system

摘要: Abstract 1. St 155 (2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride) (0.1-2.5 mg/kg subcutaneously) in rats prolonged chloral hydrate sleeping time, inhibited exploratory activity, reduced rotarod performance and pain-induced aggression; guinea-pigs conditioned avoidance behaviour was inhibited. 2. In most experiments 5-7 times more potent than chlorpromazine on a weight basis. white were equi-effective inhibiting behaviour. relatively less active lowering body temperature. 3. Chronic treatment with resulted reduction of its hypotensive sedative effects caused irritability spontaneous episodes severe fighting rats. 4. 155, at doses causing similar response inhibition, produced significant increase noradrenaline concentration all brain regions except the striate. Radioisotope studies indicate an storage without changes metabolism.