Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatment.
作者： John Treanor , Frederick G Hayden , Luis Barroso , Larisa Gubareva
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摘要: Results: In influenza A treatment, peramivir 400 mg q24h and 200mg q12h, but not lower doses, resulted in significant reductions viral titre AUC. B both 800/400 once daily dose groups reduced AUC values. prophylaxis, the percentage of individuals with nasal shedding did differ significantly placebo (58%), 50 (61%), 200 (37%) (31%) groups. frequencies were similar (55%), (41%), (35%) 800 (47%) The drug was well tolerated all four studies, nausea headache being most common side effects. No drug-resistant variants detected. Conclusion: Early treatment associated antiviral effects experimentally induced humans. Prophylaxis reduce shedding. relatively low blood concentrations observed may explain lack more robust effects, parenteral dosing should be studied.
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