Disruption of Glial Ca2+ Oscillations at the Drosophila Blood-Brain Barrier Predisposes to Seizure-Like Behavior

摘要: Abstract Glia play key roles in regulating multiple aspects of neuronal development and function from invertebrates to humans. We recently found microdomain Ca2+ signaling Drosophila cortex glia astrocytes regulate extracellular K+ buffering neurotransmitter uptake, respectively. Here we identify a role for ER store-operated entry (SOCE) perineurial (PG), distinct population that contributes the blood-brain barrier (BBB). PG show diverse range oscillatory activity varies based on their locale within brain. Unlike astrocytes, oscillations do not require are blocked by inhibition SOCE or gap junctions. Disruption these components triggers heat shock mechanical-induced seizure-like episodes without effecting morphology large molecule BBB permeability. These findings indicate SOCE-mediated increase susceptibility Drosophila, providing an additional link between glial activity.