The load of genetic and partially genetic diseases in man. II. Some selected common multifactorial diseases: Estimates of population prevalence and of detriment in terms of years of lost and impaired life

摘要: Abstract This paper presents epidemiological data on the prevalence of 26 common (i.e., having a lifetime more than 1 per 104 individuals in population) multifactorial diseases Hungary and estimates detriment associated with them. The is expressed using 3 indicators, namely years lost life (LL), potentially impaired (PIL) actually (AIL). total these has been estimated to be about 6500 population. estimate agreement published for other parts world. On basis clinical severity, have split into groups, (1) very severe (schizophrenia, multiple sclerosis, epilepsy, acute myocardial infarction related conditions, systemic lupus erythematosus); (2) moderately and/or episodal or seasonal (15 entities including Graves' disease, diabetes mellitus, gout, affective psychoses, essential hypertension, peptic ulcers, asthma, etc.); (3) less those first 2 groups (varicose veins, allergic rhinitis, atopic dermatitis, Scheuermann disease adolescent idiopathic scoliosis). genetic aspects are briefly discussed. With exception none included our list causes mortality between ages 0 19. However, they among leading death 20 69 thereafter. A sizeable proportion rheumatoid arthritis, etc. survive 70 beyond, as do glaucoma, psoriasis, Overall, 16% all deaths that occur every year (all age groups) can attributed diseases.