S100/calgranulins EN-RAGEing the blood vessels: implications for inflammatory responses and atherosclerosis.

摘要: Atherosclerosis remains the leading cause of death in western countries and represents a complex chronic inflammatory process whose regulation is dependent on network cytokine chemokine signaling between key cells such as endothelial cells, monocytes, dendritic lymphocytes smooth muscle cells. This review focuses biology function S100 proteins their receptor RAGE with respect to multifactorial atherosclerosis, plaque rupture, aortic wall remodeling.