Variations in adjuvant chemotherapy and survival in women with epithelial ovarian cancer - a population-based study.
作者： Satyamurthy Anuradha , Peter J. Donovan , Penelope M. Webb , Alison H. Brand , Jeffrey Goh
DOI: 10.3109/0284186X.2015.1054950
关键词:
摘要: Background. To investigate whether variations in primary chemotherapy were associated with survival a nationally complete cohort of Australian women epithelial ovarian cancer (EOC).Material and methods. All 1192 diagnosed invasive EOC Australia 2005 identified through state-based registries. Medical record information including details treatment was obtained data updated 2012. Those started on standard (carboplatin paclitaxel given at three-weekly intervals) after cytoreductive surgery included (n = 351) the relative dose intensity (RDI) calculated. Time interval between start analysed weeks. Hazard ratios [HR, 95% confidence (CI)] calculated using multivariable Cox proportional hazards models.Results. Compared to RDI 91–100%, those ≤ 70% had significantly poor (HRadj 1.62, CI 1.05–2.49). This associatio...
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