Molecular mechanisms of cardiac myocardial remodeling during aging. Role of apoptosis

摘要: Studies on myocardial senescence are far from being academic for several reasons, Epidemiological studies have shown that diseases of the heart one major causes mortality among overall population and main cause death in people after 65 years age (1). Therefore, it is importance to determine physiological structure function healthy aged persons assess limits normality all groups. The clinical problem simple because obviously basic process intimately associated with an increased incidence arterial hypertension, atheroclerosis, cancer, also modifications physical activity nutritional status which may seriously modify structure. It possible carefully select who normal blood pressure no history coronary disease, but anatomical demonstrated high occult stenosis die (2). would be very difficult eliminate such a disease only basis criteria. ethically organize large epidemiological study aging include routine coronarography (reviewed 2–5). advent non invasive imaging techniques as electron-beam computed tomography (6) prove value this setting. From pure economical point view, quite important know whether myocardium behaves like adult their responses various stimuli drugs, more suitable perform first screening new therapies senescent animal models.