G-CSF administered in time-sequenced setting during remission induction and consolidation therapy of adult acute lymphoblastic leukemia has beneficial influence on early recovery and possibly improves long-term outcome: a randomized multicenter study.

摘要: Sixty-four untreated adult acute lymphoblastic leukemia (ALL) patients were randomized to receive chemotherapy alone, n = 31 or and granulocyte colony stimulating factor (G-CSF), 33. During induction received G-CSF for 5 days between four weekly Epirubicin+Vcr administrations, starting 36 h after each application finishing 48 before the next one with intention possibly generate a cell cycle dependent protection of normal hematopoietic progenitors stimulate granulopoiesis. The complete remission (CR) rate equaled 94% in group 87% controls. Patients who G-CSF, if compared controls, had shorter granulocytopenia during consolidation, displayed lower infection rate, completed induction-consolidation quicker stayed hospital induction, p < 0.001-0.04. Follow-up at 2 years revealed rather higher probability survival (59 vs. 27%, 0.04) relapse (32 60%) arm than beneficial influence administered time-sequenced fashion on needs further confirmation.