Amifostine protects blood vessels from the effects of ionizing radiation.

摘要: Amifostine (WR-2721) is a well-known radioprotective drug, selective for normal cells. The purpose of the present study was to define whether amifostine protects vascular network from effects X-rays. We used in vivo system chicken embryo chorioallantoic membrane (CAM) as model angiogenesis. reversed early X-rays- induced decrease number CAM blood vessels and radiation-induced apoptosis It also inhibited increase tyrosine nitration actin a-tubulin, which observed 6 hours after irradiation, when there significant non-protein SH groups. Furthermore, C6 rat glioma cells were inoculated on tumor growth, well tumor-induced angiogenesis, estimated haematoxylin-eosin-stained paraffin sections. post irradiation These data suggest that X-rays, through mechanisms do not depend solely its free radical scavenging properties.