Leucine Regulates Translation Initiation of Protein Synthesis in Skeletal Muscle after Exercise

作者: Layne E. Norton , Donald K. Layman

DOI: 10.1093/JN/136.2.533S

关键词:

摘要: … This review focuses on the role of leucine in the regulation of skeletal muscle protein synthesis through initiation factors 4E (eIF4E) and 4G (eIF4G) and ribosomal protein S6 (rpS6). …

参考文章(36)
M. J. Rennie, R. H. T. Edwards, S. Krywawych, C. T. M. Davies, D. Halliday, J. C. Waterlow, D. J. Millward, Effect of exercise on protein turnover in man Clinical Science. ,vol. 61, pp. 627- 639 ,(1981) , 10.1042/CS0610627
G L Dohm, G J Kasperek, E B Tapscott, G R Beecher, Effect of exercise on synthesis and degradation of muscle protein Biochemical Journal. ,vol. 188, pp. 255- 262 ,(1980) , 10.1042/BJ1880255
Christopher G. Proud, Regulation of mammalian translation factors by nutrients FEBS Journal. ,vol. 269, pp. 5338- 5349 ,(2002) , 10.1046/J.1432-1033.2002.03292.X
A L Goldberg, T W Chang, Leucine inhibits oxidation of glucose and pyruvate in skeletal muscles during fasting. Journal of Biological Chemistry. ,vol. 253, pp. 3696- 3701 ,(1978) , 10.1016/S0021-9258(17)34857-3
Joshua C. Anthony, Tracy Gautsch Anthony, Donald K. Layman, Leucine Supplementation Enhances Skeletal Muscle Recovery in Rats Following Exercise Journal of Nutrition. ,vol. 129, pp. 1102- 1106 ,(1999) , 10.1093/JN/129.6.1102
Gregory L. Paul, Joan T. Rokusek, Gregory L. Dykstra, Richard A. Boileau, Donald K. Layman, Oat, Wheat or Corn Cereal Ingestion before Exercise Alters Metabolism in Humans Journal of Nutrition. ,vol. 126, pp. 1372- 1381 ,(1996) , 10.1093/JN/126.5.1372
Robert A. Harris, Rumi Kobayashi, Taro Murakami, Yoshiharu Shimomura, Regulation of Branched-Chain α-Keto Acid Dehydrogenase Kinase Expression in Rat Liver Journal of Nutrition. ,vol. 131, ,(2001) , 10.1093/JN/131.3.841S
Douglas R. Bolster, Thomas C. Vary, Scot R. Kimball, Leonard S. Jefferson, Leucine Regulates Translation Initiation in Rat Skeletal Muscle Via Enhanced eIF4G Phosphorylation Journal of Nutrition. ,vol. 134, pp. 1704- 1710 ,(2004) , 10.1093/JN/134.7.1704
Donald K. Layman, Role of Leucine in Protein Metabolism During Exercise and Recovery Canadian Journal of Applied Physiology-revue Canadienne De Physiologie Appliquee. ,vol. 27, pp. 646- 663 ,(2002) , 10.1139/H02-038
ANTON J.M. WAGENMAKERS, Muscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism. Exercise and Sport Sciences Reviews. ,vol. 26, pp. 287- 314 ,(1998) , 10.1249/00003677-199800260-00013