Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: Is Aβ a Crucial Factor in Both Pathologies?
作者： Victoria Campos-Peña , Danira Toral-Rios , Fernando Becerril-Pérez , Carmen Sánchez-Torres , Yair Delgado-Namorado
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摘要: Abstract Significance: Recently, chronic degenerative diseases have become one of the main health problems worldwide. That is case Alzheimer's disease (AD) and metabolic syndrome (MetS), whose expression can be influenced by different risk factors. Recent Advances: In recent decades, it has been widely described that MetS increases cognitive impairment dementia. pathogenesis involves several vascular factors such as diabetes, dyslipidemia, hypertension, insulin resistance (I/R). Critical Issues: Reported evidence shows are associated with AD, particularly in development protein aggregation, inflammation, oxidative stress, neuronal dysfunction, disturbances signaling pathways, receptor being a common alteration between AD. Future Directions: Insulin involved tau phosphorylation amyloid β (Aβ) metabolism. However, also demonstrated Aβ oligomers bind to ...
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