Antibody Mediated Movement Disorders and Their Differential Response to Immunomodulatory Therapy (P4.051)

摘要: OBJECTIVE: To examine six cases of antibody mediated movement disorder and their differential response to immunomodulatory therapy. BACKGROUND: Movement disorders resulting from autoantibodies are well described. There is less data on whether one therapy superior. METHODS: We retrospectively reviewed clinical all antibody-screen positive patients seen at the Disorders Clinic WFSM. Antibody titers were assessed before after treatment. Cognitive motor symptom severity was graded a 0-3 point scale (i.e. none, non bothersome, disabling) by fellowship-trained Disorder neurologist. Patient 1 had elevated serum neuronal voltage gated potassium channel antibodies (VGKC) acetylcholine receptor ganglionic (AChRGN). He presented with tremor, chorea, cognitive decline. 2 AChRGN neuropathy gait difficulty. 3 disturbance. 4 anti-GAD 65 dystonia. 5 anti-gliadin cerebellar ataxia 6 VGKC decline difficulties. Each treated therapy; including intravenous steroids, immunoglobulin, plasmapheresis (PLEX). RESULTS: Pre post treatment obtained in patients. levels found decrease proportionately symptoms. This showed trend towards correlation (R=-.06). symptoms responded more poorly than sensory In who received modality, PLEX most effective. CONCLUSION: Patients presenting unclear etiology should be screened for presence which can potentially effectively. Though larger study needed, our results suggest that reduction post-treatment potential index may effective other treatments. Disclosure: Dr. Bishop has nothing disclose. Siddiqui research support Hanes Foundation. Tate