Melatonin: Antigonadal and progonadal effects in male golden hamsters

作者: F. Turek , C. Desjardins , M. Menaker

DOI: 10.1126/SCIENCE.1179207

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摘要: Melatonin induced marked testicular regression in hamsters maintained on photostimulatory long days (light-dark 14 : 10). In animals nonstimulatory short 6 18), small amounts of melatonin (50 micrograms per day; 100 millimeters capsule length) prevented regression; but atrophy occurred that received larger (75 to 150 200 and control none. The results demonstrate can exert either pro- or antigonadal effects emphasize the testis cannot be properly assessed unless account is taken dosage mode administration photoperiod which experimental are maintained.

参考文章(19)
S. Pavel, Magdalena Petrescu, Niculina Vicoleanu, Evidence of central gonadotropin inhibiting activity of arginine vasotocin in the female mouse. Neuroendocrinology. ,vol. 11, pp. 370- 374 ,(1973) , 10.1159/000122147
IBRAHIM A. KAMBERI, RENON S. MICAL, JOHN C. PORTER, Effects of melatonin and serotonin on the release of FSH and prolactin. Endocrinology. ,vol. 88, pp. 1288- 1293 ,(1971) , 10.1210/ENDO-88-6-1288
R. J. Reiter, M. K. Vaughan, D. E. Blask, L. Y. Johnson, Melatonin: Its Inhibition of Pineal Antigonadotrophic Activity in Male Hamsters Science. ,vol. 185, pp. 1169- 1171 ,(1974) , 10.1126/SCIENCE.185.4157.1169
M. K. Vaughan, G. M. Vaughan, D. C. Klein, Arginine Vasotocin: Effects on Development of Reproductive Organs Science. ,vol. 186, pp. 938- 939 ,(1974) , 10.1126/SCIENCE.186.4167.938
Richard J. Orts, Bryant Benson, Byron F. Cook, SOME ANTIGONADOTROPHIC EFFECTS OF MELATONIN-FREE BOVINE PINEAL EXTRACTS IN RATS European Journal of Endocrinology. ,vol. 76, pp. 438- 448 ,(1974) , 10.1530/ACTA.0.0760438
R. A. Hoffman, R. J. Reiter, PINEAL GLAND: INFLUENCE ON GONADS OF MALE HAMSTERS. Science. ,vol. 148, pp. 1609- 1611 ,(1965) , 10.1126/SCIENCE.148.3677.1609
Klaus Hoffmann, Testicular involution in short photoperiods inhibited by melatonin. Naturwissenschaften. ,vol. 61, pp. 364- 365 ,(1974) , 10.1007/BF00600307