Adenovirus E1A gene-induced tumor cell rejection through cellular sensitization to immune and nonimmune apoptotic injuries.
作者： James, L. Cook
DOI: 10.2741/1628
关键词:
摘要: The E1A gene of human adenovirus (Ad) serotypes 2 and 5 induces susceptibility cells from several species, including human, to lysis by natural killer cells, activated macrophages a variety other immunologic nonimmune cellular injuries. This activity is the rationale behind some treatment strategies using combined adenoviral vector infection chemotherapy for cancer. review will consider evolution studies that have resulted in current understanding mechanisms E1A-induced tumor cell cytolytic sensitization apoptotic injury. translation vitro observations experimental models testing rejection context immune response therapeutic injuries be discussed. Review available information on molecular sensitivity used as basis consideration possible future directions this research.
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