The Future of Preclinical Animal Models in Pharmaceutical Discovery and Development A Need to Bring In Cerebro to the In Vivo Discussions

摘要: Animal models have provided an important tool to help make the decision take potential therapies from preclinical studies humans. In past several years, strong reliance of pharmaceutical discovery and development process on use animal has come under increasing scrutiny for ethical scientific reasons. Several prominent widely publicized articles reported limited concordance experiments with subsequent human clinical trials. Recent assessments quality suggested that this translational failure may be due in part shortcomings planning, conduct, reporting vivo studies. This article will emphasize methods assure best practice rigor study reporting. It introduce so-called 3Rs relevance, robustness, reproducibility approach review new trends research communities.