Caffeine Prevents Hyperoxia-Induced Functional and Structural Lung Damage in Preterm Rabbits

摘要: Background: Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have beneficial effect on bronchopulmonary dysplasia (BPD), which the most common complication extreme preterm birth. Objectives: To study inflammatory, structural and functional effects caffeine in an animal model BPD. Methods: Preterm New Zealand-Dendermonde rabbits (gestational day 28; term 31) were randomized to three groups: normoxia-placebo (N-P), hyperoxia-placebo (H-P) hyperoxia-caffeine (H-C). Lung function was assessed postnatal 5, along with airway morphometry, vascular morphometry score observing inflammation. Results: improved lung by increasing volume [mean displaced N-P: 40.1 ± 6 ml/kg, H-P: 27.8 8 ml/kg H-C: 34.4 7 (p 2O/ml, 4.6 0.6 cm H2O/ml 3.2 0.4 19.2 7.4 10.7 2 0.054 0.01 0.07 0.013 Conclusion: In rabbits, reduces functional, architectural inflammatory pulmonary changes induced hyperoxia lung.