Effects of EPO on Blood Parameters and Running Performance in Kenyan Athletes

摘要: Introduction: Recombinant human erythropoietin (rHuEpo) administration enhances oxygen carrying capacity and performance at sea level. It remains unknown whether similar effects would be observed in chronic altitude-adapted endurance runners. The aim of this study was to assess the rHuEpo on hematological parameters runners as compared level athletes. Methods: Twenty well-trained Kenyan (KEN) living training approximately 2150 m received injections 50 IU·kg−1 body mass every 2 d for 4 wk responses with another cohort (SCO) that underwent an identical protocol Blood samples were obtained baseline, during after final injection. A maximal uptake (V˙O2max) test 3000-m time trial performed before, immediately Results: Hematocrit (HCT) hemoglobin concentration (HGB) higher KEN SCO before but end administration. Before administration, had V˙O2max faster SCO. After there a increase both cohorts; most maintained injection cohorts. Conclusions: Four weeks increased HGB HCT lesser extent than (~17% vs ~10%, respectively) these alterations associated improvements running (~5%) (~3%).