Deep learning approach to peripheral leukocyte recognition.

作者: Qiwei Wang , Shusheng Bi , Minglei Sun , Yuliang Wang , Di Wang

DOI: 10.1371/JOURNAL.PONE.0218808

关键词:

摘要: Microscopic examination of peripheral blood plays an important role in the field diagnosis and control major diseases. Peripheral leukocyte recognition by manual requires medical technicians to observe smears through light microscopy, using their experience expertise discriminate analyze different cells, which is time-consuming, labor-intensive subjective. The traditional systems based on feature engineering often need ensure successful segmentation then manually extract certain quantitative qualitative features for but still remaining a limitation poor robustness. classification pipeline convolutional neural network automatic extraction free hard deal with multiple object recognition. In this paper, we take as detection task apply two remarkable approaches, Single Shot Multibox Detector An Incremental Improvement Version You Only Look Once. To improve performance, some key factors involving these approaches are explored models generated train set 14,700 annotated images. Finally, evaluate test sets consisting 1,120 images 7,868 labeled single corresponding 11 categories leukocytes, respectively. A best mean average precision 93.10% accuracy 90.09% achieved while inference time 53 ms per image NVIDIA GTX1080Ti GPU.

参考文章(45)
Shaoqing Ren, Kaiming He, Ross Girshick, Jian Sun, Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks IEEE Transactions on Pattern Analysis and Machine Intelligence. ,vol. 39, pp. 1137- 1149 ,(2017) , 10.1109/TPAMI.2016.2577031
Pierre Sermanet, Yann LeCun, David Eigen, Rob Fergus, Michael Mathieu, Xiang Zhang, OverFeat: Integrated Recognition, Localization and Detection using Convolutional Networks arXiv: Computer Vision and Pattern Recognition. ,(2013)
Motilal Agrawal, Kurt Konolige, Morten Rufus Blas, CenSurE: Center Surround Extremas for Realtime Feature Detection and Matching european conference on computer vision. pp. 102- 115 ,(2008) , 10.1007/978-3-540-88693-8_8
Ross Girshick, Fast R-CNN international conference on computer vision. pp. 1440- 1448 ,(2015) , 10.1109/ICCV.2015.169
Jaroonrut Prinyakupt, Charnchai Pluempitiwiriyawej, Segmentation of white blood cells and comparison of cell morphology by linear and naïve Bayes classifiers Biomedical Engineering Online. ,vol. 14, pp. 63- 63 ,(2015) , 10.1186/S12938-015-0037-1
Santiago Alférez, Anna Merino, Laura Bigorra, Luis Mujica, Magda Ruiz, Jose Rodellar, Automatic recognition of atypical lymphoid cells from peripheral blood by digital image analysis American Journal of Clinical Pathology. ,vol. 143, pp. 168- 176 ,(2015) , 10.1309/AJCP78IFSTOGZZJN
Seyed Hamid Rezatofighi, Hamid Soltanian-Zadeh, Automatic recognition of five types of white blood cells in peripheral blood Computerized Medical Imaging and Graphics. ,vol. 35, pp. 333- 343 ,(2011) , 10.1016/J.COMPMEDIMAG.2011.01.003
J. Ford, Red blood cell morphology International Journal of Laboratory Hematology. ,vol. 35, pp. 351- 357 ,(2013) , 10.1111/IJLH.12082
AnandS Dighe, KentB Lewandrowski, Balaji Singh, JasonM Baron, IrinaK Kamis, SidiM Belkziz, A novel strategy for evaluating the effects of an electronic test ordering alert message: Optimizing cardiac marker use Journal of Pathology Informatics. ,vol. 3, pp. 3- 3 ,(2012) , 10.4103/2153-3539.93400