Resistance to Nucleoside and Nucleotide Reverse Transcriptase Inhibitors

摘要: Long-term virological suppression of HIV replication to restore immune function is the cornerstone management. Antiretroviral regimens are becoming simpler, more potent, and better tolerated, but development drug resistance remains a significant problem. Despite very low rates failure with current in some recent clinical trials (1, 2, 3, 4), often higher practice (5-7), especially patients who treatment experienced (7, 8). Virological failure, defined as detectable plasma RNA levels after initial or inability suppress undetectable treatment, influenced by many factors, including regimen potency, patient adherence, pharmacokinetics, preexisting resistance. However, response major cause consequence (9).