CHAPTER 8 – Development of Epitope-Specific Immunotherapies for Human Malignancies and Premalignant Lesions Expressing Mutated ras Genes

摘要: This chapter focuses on an understanding of the nature biologic interactions between host cellular immune system and products activated ras genes, mainly in human systems, which may have clinical applications for development cell-mediated antitumor immunity neoplasia. It is generally thought that cancer cells are potentially antigenic but lack adequate intrinsic immunogenic properties necessary to elicit protective tumor-bearing hosts. Thus, important experimental prerequisite effective design immunotherapies neoplasms, particularly solid tumors, identification tumor-associated antigens (TAAs) or tumor-specific (TSAs) express potential regression epitopes. Once defined characterized, purified recombinant forms TAAs TSAs can then be employed use as immunogens activation relevant effector mechanisms by two major strategies: (1) active immunotherapy, involves vivo immunization vaccination; (2) passive adoptive ex expansion primed, autologous cells, returned host..