Cancer therapy using cldn6 target-directed antibodies in vivo

作者: Maria Kreuzberg , Michael Koslowski , Ozlem Tureci , Korden Walter , Ugur Sahin

DOI:

关键词:

摘要: The invention relates to the treatment and/or prevention of tumor diseases associated with cells expressing CLDN6, in particular cancer and metastasis using antibodies which bind CLDN6. present application demonstrates that binding CLDN6 on surface is sufficient inhibit growth prolong survival extend lifespan patients. Furthermore, efficient inhibiting positive germ cell tumors such as teratocarcinomas or embryonal carcinomas, testis.

参考文章(77)
Landor M, Maternal-fetal transfer of immunoglobulins. Annals of Allergy Asthma & Immunology. ,vol. 74, pp. 279- 283 ,(1995)
Ed Harlow, David Lane, Using Antibodies: A Laboratory Manual ,(1998)
Olwyn M. R. Westwood, Frank C. Hay, Epitope mapping : a practical approach Oxford University Press. ,(2000)
Maria Kreuzberg, Stefan Woll, Michael Erdeljan, Michael Koslowski, Ozlem Tureci, Korden Walter, Ugur Sahin, Michael Weichel, Bernd Hubner, Antibodies for treatment of cancer ,(2012)
Kunyuan Cui, Steven Quay, Method for diagnosing and treating cancer ,(2004)
Peter Vanlandschoot, Johannes Josephn Wilhelmus De Haard, Regorius Leurs, Michael John Scott Saunders, Peter Verheesen, Sven Jähnichen, Dominique Schols, Martine Smit, Christophe Blanchetot, Amino acid sequences targeting human cd4, cxcr4, ccr5, tlr4, alphav integrin, beta3-integrin, beta1-integrin, human alpha2-integrin, cd81, sr-bi, claudin-1, claudin-6 and claudin-9, respectively, and neutralizing viral entry ,(2009)
Heidelinde Fiegl, Peter Schulz-Knappe, Annabel Höpner, Christian Scheer, Angelika Lüking, Günter Daxenbichler, Axel Kowald, Method for identifying marker sequences for gynaecological malignant tumours ,(2012)
Barbara J. Gour, James Matthew Symonds, Orest W. Blaschuk, Compounds and methods for modulating claudin-mediated functions ,(1999)