Identifying Molecular Features Associated with Psychoneurological Symptoms in Women with Breast Cancer Using Multivariate Mixed Models

摘要: Breast cancer (BC) is the second most common among women. Research shows many women with BC experience anxiety, depression, and stress (ADS). Epigenetics has recently emerged as a potential mechanism for development of depression.1 Although there are growing numbers research studies indicating that epigenetic changes associated ADS, currently no evidence this association present in BC. The goal study was to identify high-throughput methylation sites (CpG sites) three psychoneurological symptoms (ADS) Traditionally, univariate models have been used examine relationship between each symptom; nevertheless, ADS can be treated cluster related included together multivariate linear model. Hence, an overarching compare contrast when identifying When fitting separate regression scale, 3 285,173 CpG tested were significantly depression. Two significant located on their respective genes FAM101A FOXJ1, third site cannot mapped any known gene at time. In contrast, identified 8,535 ADS-related sites. conclusion, analyzing correlated symptom outcomes, more powerful thus recommended.