LTP Requires a Unique Postsynaptic SNARE Fusion Machinery
作者： Sandra Jurado , Debanjan Goswami , Yingsha Zhang , Alfredo J. Miñano Molina , Thomas C. Südhof
DOI: 10.1016/J.NEURON.2012.11.029
关键词:
摘要: Membrane fusion during exocytosis is mediated by assemblies of SNARE (soluble NSF-attachment protein receptor) and SM (Sec1/Munc18-like) proteins. The SNARE/SM proteins involved in vesicle neurotransmitter release are well understood, whereas little known about the machinery that mediates activity-dependent AMPA receptor (AMPAR) long-term potentiation (LTP). Using direct measurements LTP acute hippocampal slices an vitro model stimulated AMPAR exocytosis, we demonstrate Q-SNARE syntaxin-3 SNAP-47 required for regulated but not constitutive basal exocytosis. In contrast, R-SNARE synaptobrevin-2/VAMP2 contributes to both Both central complexin-binding N-terminal Munc18-binding sites essential its postsynaptic role LTP. Thus, AMPARs a unique distinct from used presynaptic release.
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