The -22018A allele matches the lactase persistence phenotype in northern Chinese populations
作者： Lidan Xu , Haiming Sun , Xuelong Zhang , Jingwei Wang , Donglin Sun
DOI: 10.3109/00365520903414176
关键词:
摘要: AbstractObjective. It has been reported that some single-nucleotide polymorphisms (-13910C/T, -22018G/A, -13907C/G, -13915T/G, and -14010G/C) within the lactase gene are associated with persistence. In our previous study, we found -13910C/T is not a good predictor of persistence in Chinese populations. To obtain better understanding mechanism persistence, examined frequencies Northern China four other alleles Material methods. We evaluated allele -14010G/C six northern populations (Manchu, Mongol, Hezhen, Oroqen, Kazak, Han) using methods polymerase chain reaction–restriction fragment length polymorphism resequencing. Results. By genotyping 1092 chromosomes, frequency -22018A was highest Kazak population extremely low Han population. Although there are...
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