Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy.

摘要: In an attempt to clarify the neurochemical background of central post-stroke pain and undertake a pharmacological analysis, basic characteristics this intractable syndrome were investigated by morphine, thiamylal ketamine tests. addition, correlation between effects chronic motor cortex stimulation therapy was examined. The study employed 39 patients who had hemibody associated with dysesthesias, radiologically demonstrated lesions in thalamic area (thalamic pain, n = 25) or suprathalamic (suprathalamic 14). evaluations showed that definite reduction occurred eight cases (20.5%) morphine test, 22 (56.4%) 11 23 (47.8%) test. Based on these assessments, there no obvious difference pain. A comparison long-term follow-up results revealed ketamine-sensitive morphine-resistant displayed long-lasting therapy, whereas remaining did not show good results. We conclude classification tests could be useful for predicting therapy. It has recently been suggested excitatory amino acids may involved development However, fact only present (59.0%) sensitive test reflects complex difficulties treating