Formulation, in vitro dissolution, and ocular bioavailability of high- and low-melting phenylephrine oxazolidines.

摘要: The in vitro dissolution and the relative ocular bioavailability of high- low-melting phenylephrine oxazolidines (HMP LMP) from a nonaqueous suspension (silicone fluid) were compared. Stability-indicating HPLC assays developed for evaluation prototype formulations, which normal-phase method was necessary analysis PO, while reverse-phase required primary degradation product, (PE), following its separation formulation using short silica gel column. PO formulated as an ophthalmic silicone fluid (20 cs) because property undergoing rapid hydrolysis aqueous media. An experimental test system measuring characteristics water-immiscible multiparticulate designed to obtain profiles suspensions HMP LMP. rates, nearly identical LMP HMP, obtained assuming quasi-infinite reservoir. A assay with fluorescence detection used concentrations PE humor corneal samples. Statistical data showed that containing equal extent absorption single topical application rabbit eye. results correlated well rates