Diagnosis and significance of minimal residual disease in patients with colorectal carcinoma

摘要: Progression of malignant tumours to metastatic disease after surgery in curative intent is due usually few and with conventional diagnostic techniques undetectable residual cells. These cells must have been spread either before or during surgery. The more sensitive specific detection these various clinically relevant compartments the patients organism became possible through new immunocytochemical molecular tools. Various clinical studies underline strong prognostic impact disseminated cancer However, many technical aspects did not yet allow sufficient standardization procedures led significantly varying results among different scientific groups. It one our primary aims test, whether might guide indication for adjuvant therapies predict efficacy solid cancers.