Eficacia y seguridad de la atorvastatina en dosis altas en pacientes con enfermedad renal crónica estadio 5 en terapia de diálisis peritoneal

作者: César A Restrepo , Jesús A Castaño , None

DOI: 10.1016/J.RCCAR.2014.05.008

关键词:

摘要: Resumen Objetivo Determinar cambios en el perfil lipidico y seguridad del tratamiento con atorvastatina dosis altas (mayor o igual a 40 mg/dia) pacientes enfermedad renal cronica estadio 5. Pacientes, materiales metodos Pacientes 5 terapia de dialisis peritoneal e hipercolesterolemia, refractarios lovastatina 40 mg al dia (menos mg/dia), quienes se les asigno altas. Analisis estadistico Estudio longitudinal, retroprospectivo, correlacional, unicentrico analisis univariado bivariado. Resultados Veinte cumplieron los criterios inclusion. El tiempo fue promedio 27 meses. La utilizada 60,4 mg/dia. tendencia beneficiosa lograr metas terapeuticas las variables logro 65% para colesterol total, 50% LDL, 40% no-HDL 45% trigliceridos. Para LDL HDL encontro diferencia estadisticamente significativa entre valores iniciales finales (p  Conclusiones En 5, mayores 50 anos, la logra obtener niveles tratados, sin que su administracion lugar eventos adversos importantes.

参考文章(30)
Ann-Cathrine Johansson, Ola Samuelsson, Per-Ola Attman, Börje Haraldsson, James Moberly, Carolyn Knight–Gibson, Petar Alaupovic, Dyslipidemia in peritoneal dialysis--relation to dialytic variables. Peritoneal Dialysis International. ,vol. 20, pp. 306- 314 ,(2000) , 10.1177/089686080002000307
Suetonia C Palmer, Sankar D Navaneethan, Jonathan C Craig, David W Johnson, Vlado Perkovic, Sagar U Nigwekar, Jorgen Hegbrant, Giovanni FM Strippoli, HMG CoA reductase inhibitors (statins) for dialysis patients Cochrane Database of Systematic Reviews. ,vol. 9, pp. 1- 59 ,(2013) , 10.1002/14651858.CD004289.PUB5
Elizabeth A. Mauger, Friedrich K. Port, Wendy E. Bloembergen, Robert A. Wolfe, A comparison of cause of death between patients treated with hemodialysis and peritoneal dialysis. Journal of The American Society of Nephrology. ,vol. 6, pp. 184- 191 ,(1995) , 10.1681/ASN.V62184
Suetonia C. Palmer, Jonathan C. Craig, Sankar D. Navaneethan, Marcello Tonelli, Fabio Pellegrini, Giovanni F.M. Strippoli, Benefits and harms of statin therapy for persons with chronic kidney disease: a systematic review and meta-analysis. Annals of Internal Medicine. ,vol. 157, pp. 263- 275 ,(2012) , 10.7326/0003-4819-157-4-201208210-00007
Per-Ola Attman, Ola Samuelsson, Ann-Cathrine Johansson, James B. Moberly, Petar Alaupovic, Dialysis modalities and dyslipidemia Kidney International. ,vol. 63, pp. S110- S112 ,(2003) , 10.1046/J.1523-1755.63.S84.3.X
Wanyin Hou, Jicheng Lv, Vlado Perkovic, Lihong Yang, Na Zhao, Meg J. Jardine, Alan Cass, Hong Zhang, Haiyan Wang, Effect of statin therapy on cardiovascular and renal outcomes in patients with chronic kidney disease: a systematic review and meta-analysis. European Heart Journal. ,vol. 34, pp. 1807- 1817 ,(2013) , 10.1093/EURHEARTJ/EHT065
Neil J Stone, Jennifer G Robinson, Alice H Lichtenstein, C Noel Bairey Merz, Conrad B Blum, Robert H Eckel, Anne C Goldberg, David Gordon, Daniel Levy, Donald M Lloyd-Jones, Patrick McBride, J Sanford Schwartz, Susan T Shero, Sidney C Smith Jr, Karol Watson, Peter WF Wilson, None, 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Circulation. ,vol. 129, pp. 2889- 2934 ,(2014) , 10.1161/01.CIR.0000437738.63853.7A
Connie Newman, John Tsai, Michael Szarek, Don Luo, Eric Gibson, Comparative Safety of Atorvastatin 80 mg Versus 10 mg Derived from Analysis of 49 Completed Trials in 14,236 Patients The American Journal of Cardiology. ,vol. 97, pp. 61- 67 ,(2006) , 10.1016/J.AMJCARD.2005.07.108
BL Kasiske, Hyperlipidemia in patients with chronic renal disease. American Journal of Kidney Diseases. ,vol. 32, ,(1998) , 10.1053/AJKD.1998.V32.PM9820472
Ashish Upadhyay, Amy Earley, Jenny L. Lamont, Shana Haynes, Christoph Wanner, Ethan M. Balk, Lipid-Lowering Therapy in Persons With Chronic Kidney Disease: A Systematic Review and Meta-analysis Annals of Internal Medicine. ,vol. 157, pp. 251- 262 ,(2012) , 10.7326/0003-4819-157-4-201208210-00005