Collagen-receptor signaling in health and disease

摘要: Collagens are not only essential for the mechanical resistance and resilience of multicellular organisms, but also signaling molecules defining cellular shape behavior. The communication between collagens cells is achieved by cell surface receptors. Three types receptors collagen known: integrins, discoidin domain glycoprotein VI. All three independently trigger a variety pathways upon collagen-binding. Besides regulating numerous responses, both integrin monitor integrity collagenous extracellular matrix triggering degradation renewal. Some recently discovered mechanisms locally controlled expression collagen, collagen-binding collagen-degrading proteases in microenvironment described.